Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
cnr1_human 405 8.51x51 H8 R => Ter stop gained 8.239e-06 1 121376 0 None None GP (contact)
cnr1_human 47 N-term K => Ter stop gained 1.648e-05 2 121390 0 None None
cnr1_human 20 N-term L => Ter stop gained 2.472e-05 3 121378 0 None None
cnr1_human 471 C-term A => S missense 8.309e-06 1 120358 0 nan 0.888
cnr1_human 463 C-term V => A missense 8.257e-06 1 121114 0 1.0 0.338
cnr1_human 462 C-term S => F missense 8.254e-06 1 121158 0 0.01 0.959
cnr1_human 452 C-term S => T missense 8.237e-06 1 121402 0 0.8 0.003
cnr1_human 450 C-term I => T missense 8.237e-06 1 121402 0 0.36 0.108
cnr1_human 446 C-term A => T missense 8.237e-06 1 121406 0 0.18 0.843
cnr1_human 446 C-term A => S missense 8.237e-06 1 121406 0 0.18 0.829
cnr1_human 444 C-term R => G missense 8.236e-06 1 121412 0 0.09 0.086
cnr1_human 442 C-term V => G missense 3.295e-05 4 121412 0 0.38 0.033
cnr1_human 436 C-term A => T missense 7.413e-05 9 121412 0 0.32 0.005
cnr1_human 435 C-term H => Y missense 8.236e-06 1 121412 0 0.06 0.126
cnr1_human 431 C-term C => Y missense 8.236e-06 1 121412 0 0.19 0.312
cnr1_human 423 C-term D => N missense 2.471e-05 3 121404 0 0.04 0.962
cnr1_human 419 C-term A => E missense 0.0003789 46 121400 0 0.33 0.22
cnr1_human 419 C-term A => V missense 1.647e-05 2 121400 0 0.22 0.104
cnr1_human 417 C-term G => C missense 8.237e-06 1 121398 0 0.0 0.974
cnr1_human 416 C-term E => K missense 8.237e-06 1 121398 0 0.48 0.004
cnr1_human 412 8.58x58 H8 F => C missense 4.119e-05 5 121392 0 0.21 0.004
cnr1_human 410 8.56x56 H8 S => N missense 8.238e-06 1 121386 0 0.83 0.007
cnr1_human 409 8.55x55 H8 R => Q missense 1.648e-05 2 121384 0 0.36 0.201
cnr1_human 409 8.55x55 H8 R => W missense 8.238e-06 1 121384 0 0.05 0.635
cnr1_human 407 8.53x53 H8 A => T missense 3.295e-05 4 121378 0 0.01 0.999
cnr1_human 364 6.56x56 TM6 V => M missense 8.265e-06 1 120986 0 0.04 0.815
cnr1_human 352 6.44x44 TM6 L => V missense 8.291e-06 1 120612 0 0.03 0.999 SodiumPocket MicroSwitch
cnr1_human 351 6.43x43 TM6 V => L missense 2.488e-05 3 120564 0 0.01 0.728
cnr1_human 340 6.32x32 TM6 R => M missense 1.664e-05 2 120228 0 0.14 1.0 GP (contact)
cnr1_human 337 6.29x29 TM6 M => V missense 1.664e-05 2 120190 0 0.0 0.994 GP (contact)
cnr1_human 336 6.28x28 TM6 R => C missense 8.323e-06 1 120148 0 0.0 1.0 GP (contact)
cnr1_human 331 ICL3 R => Q missense 8.331e-06 1 120038 0 0.19 0.999
cnr1_human 331 ICL3 R => W missense 8.331e-06 1 120032 0 0.01 1.0
cnr1_human 328 ICL3 Q => E missense 8.33e-06 1 120052 0 0.06 0.209
cnr1_human 326 ICL3 K => N missense 8.331e-06 1 120038 0 0.06 0.99
cnr1_human 321 ICL3 T => K missense 2.498e-05 3 120082 0 0.04 0.41
cnr1_human 321 ICL3 T => M missense 4.164e-05 5 120082 0 0.01 0.832
cnr1_human 318 ICL3 I => S missense 2.498e-05 3 120116 0 0.01 0.88
cnr1_human 317 ICL3 I => M missense 8.325e-06 1 120124 0 0.38 0.071
cnr1_human 317 ICL3 I => V missense 8.324e-06 1 120130 0 0.53 0.007
cnr1_human 312 5.76x76 TM5 G => D missense 8.322e-06 1 120168 0 0.2 0.601
cnr1_human 311 5.75x75 TM5 R => H missense 8.32e-06 1 120188 0 0.25 1.0 GP (contact)
cnr1_human 311 5.75x75 TM5 R => C missense 8.32e-06 1 120192 0 0.0 1.0 GP (contact)
cnr1_human 307 5.71x71 TM5 R => H missense 2.496e-05 3 120216 0 0.08 0.115 GP (contact)
cnr1_human 307 5.71x71 TM5 R => C missense 8.318e-06 1 120216 0 0.08 0.97 GP (contact)
cnr1_human 306 5.70x70 TM5 V => I missense 4.159e-05 5 120228 0 0.06 0.932
cnr1_human 305 5.69x69 TM5 A => T missense 2.495e-05 3 120250 0 0.23 0.733 GP (contact)
cnr1_human 299 5.63x63 TM5 W => R missense 8.309e-06 1 120350 0 0.02 1.0
cnr1_human 293 5.57x57 TM5 A => V missense 8.306e-06 1 120400 0 0.0 1.0
cnr1_human 291 5.55x55 TM5 V => L missense 4.152e-05 5 120434 0 0.19 0.327
cnr1_human 285 5.49x49 TM5 V => I missense 0.0001494 18 120522 0 0.58 0.016
cnr1_human 274 5.38x38 TM5 T => S missense 1.658e-05 2 120636 0 0.5 0.122
cnr1_human 271 ECL2 I => T missense 8.288e-06 1 120656 0 0.0 0.999
cnr1_human 249 4.58x58 TM4 V => M missense 8.279e-06 1 120790 0 0.13 0.954 LB (hydrophobic)
cnr1_human 248 4.57x57 TM4 A => T missense 8.277e-06 1 120816 0 0.01 0.754 LB (hydrophobic)
cnr1_human 243 4.52x52 TM4 I => M missense 8.273e-06 1 120876 0 0.02 0.938
cnr1_human 243 4.52x52 TM4 I => T missense 8.274e-06 1 120864 0 0.37 0.932
cnr1_human 239 4.48x48 TM4 L => M missense 8.274e-06 1 120860 0 0.41 0.018
cnr1_human 234 4.43x43 TM4 V => M missense 8.279e-06 1 120790 0 0.12 0.991
cnr1_human 231 4.40x40 TM4 P => T missense 8.279e-06 1 120782 0 0.61 0.003
cnr1_human 229 4.38x38 TM4 T => S missense 8.279e-06 1 120788 0 0.0 0.999
cnr1_human 186 3.22x22 TM3 R => L missense 8.293e-06 1 120588 0 0.03 0.076
cnr1_human 185 3.21x21 TM3 S => N missense 5.804e-05 7 120608 0 0.04 0.974
cnr1_human 179 2.66x66 TM2 V => M missense 8.292e-06 1 120596 0 0.0 0.997
cnr1_human 168 2.55x55 TM2 V => A missense 1.659e-05 2 120570 0 0.06 0.821
cnr1_human 164 2.51x51 TM2 L => F missense 2.489e-05 3 120540 0 0.32 1.0
cnr1_human 160 2.47x47 TM2 A => V missense 8.318e-06 1 120214 0 0.0 1.0
cnr1_human 157 2.44x44 TM2 G => S missense 3.324e-05 4 120352 0 0.45 0.261
cnr1_human 157 2.44x44 TM2 G => R missense 8.309e-06 1 120352 0 0.0 0.959
cnr1_human 151 2.38x38 TM2 P => A missense 1.659e-05 2 120534 0 0.0 0.999
cnr1_human 146 12.49x49 ICL1 S => R missense 8.284e-06 1 120708 0 0.68 0.724
cnr1_human 145 12.48x48 ICL1 R => H missense 4.143e-05 5 120674 0 0.43 0.185
cnr1_human 145 12.48x48 ICL1 R => S missense 8.281e-06 1 120752 0 0.75 0.884
cnr1_human 140 1.56x56 TM1 V => I missense 8.268e-06 1 120944 0 0.1 0.62
cnr1_human 133 1.49x49 TM1 E => G missense 8.259e-06 1 121086 0 0.01 0.999
cnr1_human 120 1.36x36 TM1 A => S missense 8.246e-06 1 121270 0 0.06 0.802
cnr1_human 113 1.29x29 TM1 P => S missense 8.243e-06 1 121316 0 0.41 0.46
cnr1_human 97 N-term Q => R missense 4.12e-05 5 121364 0 0.12 0.209
cnr1_human 93 N-term E => K missense 0.0001566 19 121358 0 0.62 0.046
cnr1_human 87 N-term S => L missense 5.768e-05 7 121358 0 nan 0.058
cnr1_human 78 N-term I => T missense 8.241e-06 1 121338 0 nan 0.013
cnr1_human 78 N-term I => V missense 8.241e-06 1 121342 0 nan 0.001
cnr1_human 76 N-term V => L missense 8.241e-06 1 121344 0 nan 0.0
cnr1_human 75 N-term Q => E missense 1.648e-05 2 121340 0 nan 0.013
cnr1_human 74 N-term D => G missense 1.648e-05 2 121344 0 nan 0.031
cnr1_human 73 N-term A => P missense 8.241e-06 1 121340 0 nan 0.054
cnr1_human 67 N-term N => S missense 1.648e-05 2 121344 0 nan 0.0
cnr1_human 64 N-term A => V missense 4.121e-05 5 121338 0 nan 0.021
cnr1_human 63 N-term T => P missense 8.24e-06 1 121354 0 nan 0.004
cnr1_human 62 N-term M => T missense 8.24e-06 1 121354 0 nan 0.051
cnr1_human 59 N-term Q => R missense 8.24e-06 1 121360 0 nan 0.001
cnr1_human 59 N-term Q => E missense 8.24e-06 1 121356 0 nan 0.014
cnr1_human 55 N-term G => A missense 9.888e-05 12 121358 0 nan 0.118
cnr1_human 55 N-term G => R missense 8.24e-06 1 121358 0 nan 0.015
cnr1_human 43 N-term Y => C missense 8.237e-06 1 121402 0 0.02 0.628
cnr1_human 37 N-term M => I missense 8.237e-06 1 121404 0 nan 0.0
cnr1_human 34 N-term K => R missense 0.0001483 18 121404 0 nan 0.908
cnr1_human 31 N-term E => K missense 1.647e-05 2 121398 0 nan 0.122
cnr1_human 30 N-term Y => H missense 8.238e-06 1 121394 0 nan 0.996
cnr1_human 27 N-term D => G missense 7.414e-05 9 121388 0 nan 0.523
cnr1_human 26 N-term N => S missense 8.238e-06 1 121384 0 nan 0.971
cnr1_human 23 N-term V => M missense 0.0001401 17 121330 0 nan 0.002
cnr1_human 15 N-term T => S missense 8.288e-06 1 120650 0 0.0 0.987 PTM (Phosphorylation)
cnr1_human 14 N-term R => H missense 5.808e-05 7 120532 0 0.0 0.996
cnr1_human 14 N-term R => C missense 8.299e-06 1 120494 0 0.0 0.997
cnr1_human 13 N-term F => V missense 1.662e-05 2 120346 0 0.0 0.986
cnr1_human 7 N-term G => D missense 8.447e-05 10 118388 0 0.0 1.0
cnr1_human 4 N-term I => N missense 8.53e-06 1 117240 0 nan 0.518
cnr1_human 3 N-term S => L missense 2.567e-05 3 116890 0 0.0 0.99


Residue

Diagrams

ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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